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    Methods for the Synthesis of Cannabinergic Ligands

    During the last decade, numerous cannabinergic ligands with high affinity and selectivity profiles for cannabinoid receptors (CB1 and CB2) emerged from rigorously pursued structure-activity relationship studies. ...

    Ganesh A. Thakur, Spyros P. Nikas in Marijuana and Cannabinoid Research (2006)

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    Chemical Database Preparation for Compound Acquisition or Virtual Screening

    手机体育投注平台 Virtual and high-throughput screening are time-saving techniques that have been successfully applied to identify novel chemotypes in biologically active molecules. Both methods require the ability to aptly han...

    Cristian G. Bologa, Marius M. Olah, Tudor I. Oprea in Bioinformatics and Drug Discovery (2006)

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    Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics

    手机体育投注平台 Elucidation of the entire human genomic sequence is one of the greatest achievements of science. Understanding the functional role of 30,000 human genes and more than 2 million polymorphisms was possible throu...

    Omer Iqbal, Jawed Fareed in Bioinformatics and Drug Discovery (2006)

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    The Bioassay of Cannabinoids Using the Mouse Isolated Vas Deferens

    The mouse isolated vas deferens is a nerve-smooth muscle preparation that serves as a highly sensitive and quantitative functional in vitro bioassay for cannabinoid CB1 receptor agonists. Additionally, it is comm...

    Adèle Thomas, Roger G. Pertwee in Marijuana and Cannabinoid Research (2006)

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    Molecular Neurobiological Methods in Marijuana-Cannabinoid Research

    手机体育投注平台 Recent aggregation of evidence for the roles of endogenous agonist and receptor systems that are mimicked or activated by cannabanoid ligands has provided a focus for work that has elucidated details of some o...

    George R. Uhl, Hiroki Ishiguro, Emmanuel S. Onaivi in Marijuana and Cannabinoid Research (2006)

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    From Microarray to Biological Networks

    Powerful new methods, such as expression profiles using cDNA arrays, have been used to monitor changes in gene expression levels as a result of a variety of metabolic, xenobiotic, or pathogenic challenges. Thi...

    Xiwei Wu, T. Gregory Dewey in Bioinformatics and Drug Discovery (2006)

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    New Strategies in Drug Discovery

    手机体育投注平台 Gene identification followed by determination of the expression of genes in a given disease and understanding of the function of the gene products is central to the drug discovery process. The ability to assoc...

    Eliot H. Ohlstein, Anthony G. Johnson, John D. Elliott in Bioinformatics and Drug Discovery (2006)

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    Methods for Clinical Research Involving Cannabis Administration

    Better scientific understanding of cannabis effects and the development of treatments for cannabis dependence require clinical studies involving cannabis administration. Cannabis can be administered by smoking...

    David A. Gorelick, Stephen J. Heishman in Marijuana and Cannabinoid Research (2006)

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    Morphometric Study on Cytoskeletal Components of Neuronal and Astroglial Cells After a Chronic CB1 Agonist Treatment

    手机体育投注平台 One of the major goals for the use of digital image analysis systems in neuroanatomy is to visualize structures, cells, or other tissue components in order to compare various populations. In addition, digital ...

    Patricia Tagliaferro, Alberto J. Ramos in Marijuana and Cannabinoid Research (2006)

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    Bioinformatics Platform Development

    In the past 10 yr, the field of bioinformatics has been characterized by the mapping of many genomes. These efforts have stimulated explosive development of novel bioinformatics and experimental approaches to ...

    Alexis S. Ivanov, Alexander V. Veselovsky in Bioinformatics and Drug Discovery (2006)

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    Receptor-Binding Sites

    手机体育投注平台 It is increasingly clear that both transient and long-lasting interactions between biomacromolecules and their molecular partners are the most fundamental of all biological mechanisms and lie at the conceptual...

    Darren R. Flower in Bioinformatics and Drug Discovery (2006)

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    Experimental Methods to Study the Role of the Peripheral Cannabinoid Receptor in Immune Function

    手机体育投注平台 Marijuana components, such as Δ-9-tetrahydrocannabinol, and endogenous cannabinoids, such as anandamide and 2-arachydonoylglycerol, alter diverse immune functions. Two cannabinoid receptors have been discovere...

    Nancy E. Buckley, Diep Burbridge, Manop Buranapramest in Marijuana and Cannabinoid Research (2006)

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    Protein Interactions Probed With Mass Spectrometry

    手机体育投注平台 Understanding the interactions of proteins with other proteins and/or with drug molecules is essential for understanding the progression of diseases. In this chapter, we present several methods utilizing mass ...

    Suma Kaveti, John R. Engen in Bioinformatics and Drug Discovery (2006)

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    Standardization of Microarray and Pharmacogenomics Data

    This chapter provides a bottom-up perspective on bioinformatics data standards, beginning with a historical perspective on biochemical nomenclature standards. Various file format standards were soon developed ...

    Casey S. Husser, Jeffrey R. Buchhalter, O. Scott Raffo in Bioinformatics and Drug Discovery (2006)

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    Microarray Analysis in Drug Discovery and Clinical Applications

    DNA microarray analyzes genome-wide gene expression patterns and is used in many areas including drug discovery and clinical applications. This chapter summarizes some of these applications such as identificat...

    Siqun Wang, Qiong Cheng in Bioinformatics and Drug Discovery (2006)

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    Nuclear Magnetic Resonance-Based Screening Methods for Drug Discovery

    手机体育投注平台 Nuclear magnetic resonance (NMR) techniques are widely used in the drug discovery process. The primary feature exploited in these investigations is the large difference in mass between drugs and receptors (usu...

    Laurel O. Sillerud, Richard S. Larson in Bioinformatics and Drug Discovery (2006)

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    Neurological Assessments of Marijuana Users

    手机体育投注平台 This chapter summarizes the neurological approaches used to assess the potential long-term effects of drugs on the nervous system of drug abusers. These include the use of neuropsychological assessments, trans...

    Jean Lud Cadet, Karen Bolla, Ronald I. Herning in Marijuana and Cannabinoid Research (2006)

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    Localization of Cannabinoid Receptors Using Immunoperoxidase Methods

    Two cannabinoid receptors have been identified to date. The first of these, designated CB1手机体育投注平台, is localized primarily in the central nervous system but is also present at lower levels in other tissues. The second re...

    Guy A. Cabral in Marijuana and Cannabinoid Research (2006)

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    Cannabinoid Receptor Binding to Membrane Homogenates and Cannabinoid-Stimulated [35S]GTP-S Binding to Membrane Homogenates or Intact Cultured Cells

    手机体育投注平台 Radioligand-binding assays can be used to obtain information about the binding characteristics of a ligand to its receptor or the general location of binding sites within a tissue or even provide evidence for ...

    Christopher Breivogel in Marijuana and Cannabinoid Research (2006)

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    Discovering New Drug-Targeting Sites on Flexible Multidomain Protein Kinases

    A novel structure-based approach to study the structure and dynamics of flexible multi-domain monomeric protein kinases, which otherwise do not yield diffraction quality crystals, is described. A combination o...

    Thomas K. Harris in Bioinformatics and Drug Discovery (2006)

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