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    Protocol

    Cloning and Detection of Aptamer-Ribozyme Conjugations

    手机体育投注平台 RNA aptamers can be used to target proteins or nucleic acids for therapeutic purposes and are candidates for RNA-mediated gene therapy. Like other small therapeutic RNAs, they can be expressed in cells from DN...

    Ryan P. Goguen, Anne Gatignol, Robert J. Scarborough in Ribozymes (2021)

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    Reference Work Entry In depth手机体育投注平台

    PKR and HIV Replication

    Anne Gatignol in Encyclopedia of AIDS (2018)

  3. 手机体育投注平台 Article

    Open Access

    Tribute to Mark Wainberg

    手机体育投注平台

    Eric J. Arts, Anne Gatignol, Andrew J. Mouland, Chen Liang, Matthias Götte in Retrovirology (2017)

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    Living Reference Work Entry In depth

    PKR and HIV Replication

    Anne Gatignol in Encyclopedia of AIDS

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    Protocol

    Design and Evaluation of Clinically Relevant SOFA-HDV Ribozymes Targeting HIV RNA

    Nucleic acid therapies targeting HIV replication have the potential to be used in conjunction with or in place of the standard small-molecule therapies. Among the different classes of nucleic acid therapies, s...

    Robert J. Scarborough, Michel V. Lévesque in Therapeutic Applications of Ribozymes and … (2014)

  6. Article

    Open Access

    HIV-1 replication changes the function of the PKR activator PACT

    Guerline Clerzius, Eileen Shaw, Aïcha Daher, Samantha Burugu in Retrovirology (2013)

  7. Article

    Open Access

    The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication

    HIV-1 translation is modulated by the activation of the interferon (IFN)-inducible Protein Kinase RNA-activated (PKR). PKR phosphorylates its downstream targets, including the alpha subunit of the eukaryotic t...

    Guerline Clerzius, Eileen Shaw, Aïcha Daher, Samantha Burugu in Retrovirology (2013)

  8. 手机体育投注平台 Article

    Open Access

    Inhibition of HIV-1 expression and replication by SOFA-HDV ribozymes against Tat and Rev mRNA sequences

    Sébastien Lainé, Robert J Scarborough, Dominique Lévesque in Retrovirology (2009)

  9. 手机体育投注平台 Article

    Open Access

    Characterization of the TRBP domain required for Dicer interaction and function in RNA interference

    Dicer, Ago2 and TRBP are the minimum components of the human RNA-induced silencing complex (RISC). While Dicer and Ago2 are RNases, TRBP is the double-stranded RNA binding protein (dsRBP) that loads small inte...

    Sylvanne M Daniels, Carlos E Melendez-Peña, Robert J Scarborough in BMC Molecular Biology (2009)

  10. Article

    Open Access

    New pandemics: HIV and AIDS, HCV and chronic hepatitis, Influenza virus and flu

    手机体育投注平台 New pandemics are a serious threat to the health of the entire world. They are essentially of viral origin and spread at large speed. A meeting on this topic was held in Lyon, France, within the XIXth Jacques ...

    Anne Gatignol, Jean Dubuisson, Mark A Wainberg, Éric A Cohen in Retrovirology (2007)

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    Open Access

    Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity?

    手机体育投注平台 Increasing evidence indicates that RNA interference (RNAi) may be used to provide antiviral immunity in mammalian cells. Human micro (mi)RNAs can inhibit the replication of a primate virus, whereas a virally-e...

    Anne Gatignol, Sébastien Lainé, Guerline Clerzius in Retrovirology (2005)

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    手机体育投注平台 Article

    Expression of TAR RNA-binding protein in baculovirus and co-immunoprecipitation with insect cell protein kinase

    手机体育投注平台 TAR RNA-binding protein TRBP was originally isolated by its binding affinity for radiolabeled HIV-1 leader RNA. Subsequent studies have suggested that this protein is one member of a family of double-stranded ...

    Dr. Edward D. Blair, Christopher M. Roberts in Journal of Biomedical Science (1995)

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    手机体育投注平台 Article

    Phleomycin resistance as a dominant selectable marker in CHO cells

    The Tn5 and the Streptoalloteichus hindustanus (Sh) ble genes conferring resistance to bleomycin-phleomycin antibiotics have been cloned into a mammalian vector under the RSV-LTR promoter. The resulting plasmi.....

    Philippe Mulsant, Anne Gatignol, Maurice Dalens in Somatic Cell and Molecular Genetics (1988)

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    手机体育投注平台 Article

    Phleomycin resistance encoded by the ble gene from transposon Tn 5 as a dominant selectable marker in Saccharomyces cerevisiae

    Phleomycin, a water-soluble antibiotic of the bleomycin family is as effective against Saccharomyces cerevisiae cells as against Escherichia coli cells. The ble gene of transposon Tn5手机体育投注平台, which confers resistance to...

    Anne Gatignol, Michel Baron, Gérard Tiraby in Molecular and General Genetics MGG (1987)